Advancements in ocular drug delivery

Fonte: Alan L. Weiner and Brian C. Gilger

Various methods for delivery of drugs to the anterior and posterior chambers of the eye are illustrated, including sites for conventional delivery as well as implant routes
   Various methods for delivery of drugs to the anterior and posterior chambers of the eye are illustrated, including sites for conventional delivery as well as implant routes

This review covers both noninvasive and invasive ophthalmic drug delivery systems that can have application to therapy of veterinary ophthalmic diseases. Noninvasive approaches include gel technologies, permeation enhancement via pro-drug development, solubilization agents and nanoparticle technologies, iontophoresis, microneedles, drug-eluting contact lenses and eye misters, and microdroplets. More invasive systems include both eroding implants and noneroding technologies that encompass diffusion based systems, active pumps, intraocular lenses, suprachoroidal drug delivery, and episcleral reservoirs. In addition to addressing the physiologic challenges of achieving the necessary duration of delivery, tissue targeting and patient compliance, the commercial development factors of biocompatibility, sterilization, manufacturability and long-term stability will be discussed.

 

Visualize e/ou imprima o artigo na integra em PDF Clicando Aqui.

 

 

© 2016 Vetweb. All rights reserved | Design by GrupoVoxx.com | Administração

>