Optical coherence tomography and molecular analysis of SARDS eyes suggests the immune‐mediated nature of retinal damage

Fonte: Sinisa D. Grozdanic

Different fundus in SARDS patients.
   Different fundus in SARDS patients.

Objective:To perform detailed analysis of retinal changes in dogs with SARDS using optical coherence tomography (OCT), funduscopy, and molecular analysis.Animals:Subjects were 29 dogs from 12 US states and Canada diagnosed withSARDS by 8 ophthalmologists. An additional 7 eyes from 5 deceased SARDS dogs were used for molecular and histological analysis.Procedures:Dogs were evaluated using chromatic pupil light reflex testing(cPLR), and electroretinography (ERG); subjects underwent complete ophthalmic examination, including funduscopy, retinal photography, and OCT, in addition to complete laboratory analysis, blood pressure evaluation, abdominal and thoracic radiographs, and computerized tomography (CT) imaging to assess possible systemic abnormalities. Histology and immunohistochemistry analysis was performed in 2 SARDS eyes. Microarray analysis was performed in 5 SARDS retinas.Results:Thirty‐eight percent of patients had


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