Systemic absorption and renal effects of topical ophthalmic flurbiprofen and diclofenac in healthy cats
Fonte: Rick Lanuza, Amy J. Rankin, Butch KuKanich and Jessica M. Meekins
Eye drops in a cat.
Objective: To investigate systemic absorption and renal effects of topically applied ophthalmic flurbiprofen and diclofenac in healthy cats. Animals studied Twelve domestic shorthair cats. Procedures Cats were randomly assigned to two treatment groups (n = 6) and administered one drop (approximately 40 lL) of either flurbiprofen 0.03% or diclofenac 0.1% in both eyes four times daily (6 am, 12 pm, 6 pm, and 12 am) for 14 days. Blood samples were collected on days 0, 4, 8, 14, 16, and 17 and analyzed by liquid chromatography and mass spectrometry for flurbiprofen and diclofenac plasma concentrations. A complete blood count (CBC), serum chemistry, and urinalysis were analyzed at the beginning of the study (Day 0) and at the end of topical drug administration (Day 15). Results: Both drugs demonstrated systemic absorption. Flurbiprofen was detected (mean SD) at day 4 (237 65 ng/mL), day 8 (396 91 ng/mL), day 14 (423 56 ng/mL), day 16 (350 66 ng/mL), and day 17 (270 62 ng/mL), and diclofenac was detected (mean SD) at day 4 (130 44 ng/mL), day 8 (131 25 ng/mL), day 14 (150 36 mg/mL), and sporadically on day 16. Flurbiprofen plasma concentration decreased slowly over 48 h after the last dose. No clinically significant abnormalities were noted in the serum blood urea nitrogen, creatinine, or urine specific gravity at the end of topical drug administration compared to the beginning of the study. Conclusions: Flurbiprofen and diclofenac were systemically absorbed after topical administration four times daily to both eyes of healthy cats. Flurbiprofen reached higher plasma concentrations compared to diclofenac.