Systemic absorption and renal effects of topical ophthalmic flurbiprofen and diclofenac in healthy cats

Fonte: Rick Lanuza, Amy J. Rankin, Butch KuKanich and Jessica M. Meekins

Eye drops in a cat.
   Eye drops in a cat.

Objective: To investigate systemic absorption and renal effects of topically applied ophthalmic flurbiprofen and diclofenac in healthy cats. Animals studied Twelve domestic shorthair cats. Procedures Cats were randomly assigned to two treatment groups (n = 6) and administered one drop (approximately 40 lL) of either flurbiprofen 0.03% or diclofenac 0.1% in both eyes four times daily (6 am, 12 pm, 6 pm, and 12 am) for 14 days. Blood samples were collected on days 0, 4, 8, 14, 16, and 17 and analyzed by liquid chromatography and mass spectrometry for flurbiprofen and diclofenac plasma concentrations. A complete blood count (CBC), serum chemistry, and urinalysis were analyzed at the beginning of the study (Day 0) and at the end of topical drug administration (Day 15). Results: Both drugs demonstrated systemic absorption. Flurbiprofen was detected (mean  SD) at day 4 (237  65 ng/mL), day 8 (396  91 ng/mL), day 14 (423  56 ng/mL), day 16 (350  66 ng/mL), and day 17 (270  62 ng/mL), and diclofenac was detected (mean  SD) at day 4 (130  44 ng/mL), day 8 (131  25 ng/mL), day 14 (150  36 mg/mL), and sporadically on day 16. Flurbiprofen plasma concentration decreased slowly over 48 h after the last dose. No clinically significant abnormalities were noted in the serum blood urea nitrogen, creatinine, or urine specific gravity at the end of topical drug administration compared to the beginning of the study. Conclusions: Flurbiprofen and diclofenac were systemically absorbed after topical administration four times daily to both eyes of healthy cats. Flurbiprofen reached higher plasma concentrations compared to diclofenac.

 

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