Clinical effect of four different ointment bases on healthy cat eyes
Fonte: Reka Eordogh, Ilse Schwendenwein, Alexander Tichy, Igor Loncaric, and Barbara Nell
Note the slight blepharospasm, marked epiphora, and increased nasal discharge that resulted in brown discoloration of the nose 5 days after topical ointment was started.
Objective: To describe the effects of long-term treatment with four different eye ointment bases (OBs) in cats.Animals studied Ten healthy cats.Procedures The study was performed in two periods. Four different OBs were tested.Hundred grams of OB contained the following: OB -A: 35.17 g liquid paraf?n (lp),64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C:18.34 g lp, 51.40 g wp, 25.00 mg KH2PO4, 57.00 mg K2HPO4, 18.90 g eucerinumanhydricum, 11.28 g water for injections; and OB-D: 70 g unguentum lanalcoli, 20 glp, 10 g aqua conservans. One eye was treated, and the other served as a negative control. Cats received the OBs TID for 28 days. The two study periods were separated by a 4-month washout phase. Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV-1 and Chlamydophila felis PCR detection were obtained. Both eyes were examined daily.Severity of ocular symptoms was scored using a modi?ed Draize eye irritation test. A total of ?ve eyes were treated with OB-A, ?ve with OB-B, four with OB-C, and ?vewith OB-D. Results: Treated eyes had signi?cantly higher clinical scores. Eyes receiving OB-A had the highest overall clinical score. The results of bacteriologic and mycologic examination concur with the previously published data. All samples tested were negative for FHV-1 and Chlamydophila felis. There was no signi?cant difference between treated and control eyes upon cytological examination. Conclusion: The application of OBs resulted in clinical symptoms in treated eyes. The long-term use of ointments is not well tolerated in cats and may lead to ocular irritation.