The effects of ketamine-midazolam anesthesia on intraocular pressure in clinically normal dogs
Fonte: Masoud Selk Ghaffari, Mohammad Ali Rezaei, Amir Hessam Mirani and Nargess Khorami
Dr. JAK realizando uma Facoemulsificação.
Objective: To determine the effects of intravenous ketamine-midazolam anesthesia on intraocular pressure (IOP) in ocular normotensive dogs. Animals Thirteen adult mixed-breed dogs. Procedures: Dogs were randomly assigned to treatment (n = 7) and control (n = 6) groups. Dogs in the treatment group received intravenous ketamine 15 mg/kg and midazolam 0.2 mg/kg and dogs in the control group received intravenous saline. The time of intravenous drug injection was recorded (T0). Measurements of IOP were then repeated 5 min (T5) and 20 min (T20) following the intravenous administration of ketamine-midazolam combination and saline in both groups. Results: Measurements showed normal IOP values in both groups. The mean ± SD baseline IOP values for treatment and control groups were 13.00 ± 1.47 and 10.33 ± 2.20, respectively. For baseline IOP values, there was no significant difference between treatment and control groups (P = 0.162). In the treatment group, the subsequent post-treatment mean ± SD values were 15.64 ± 2.17 (5 min), and 14.92 ± 1.98 (20 min). There was no evidence of statistical difference between baseline values and post-treatment values after treatment with ketamine-midazolam (P5 = 0.139; P20 = 0.442). In control eyes, the mean ± SD values at 5 and 20 min were 10.41 ± 2.01 and 10.16 ± 1.69, respectively. There was no significant difference between baseline values and post-treatment values in control group (P5 = 1.000; P20 = 1.000). Conclusion: Ketamine-midazolam combination has no clinically significant effect on IOP in the dog.